Antigen synonymer, gp130,IL-6R Beta. Antikroppstyp, Primary. Klonalitet, Polyclonal. Konjugation, Unconjugated. Reaktivitet, Human,Rat,Mouse. Värd, Rabbit.

Gp130, a shared signal transducing receptor component for hematopoietic and neuropoietic cytokines J Neurochem. 1996 Jul;67(1):1-10. doi: 10.1046/j.1471-4159.1996.67010001.x. Author T Taga 1 Affiliation 1 Institute for Molecular

gp130 is a potential therapeutic target to improve heart regeneration after cardiac injury. INTRODUCTION: Ubiquitously expressed in the human body, glycoprotein 130 (gp130) is a shared subunit of receptor complexes for at least nine cytokines (IL-6, OSM, LIF, IL-11, CNTF, CLC, IL-27, CT-1, and NP) that mediate highly diverse biological processes. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses Signal transduction in response to interleukin-6 (IL-6) requires binding of the cytokine to its receptor (IL-6R) and subsequent homodimerization of the signal transducer gp130. GP130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines (1-3).

Gp130

The interleukin-6 (IL-6) cytokine family, defined by its use of the glycoprotein 130 (gp130) co-receptor, includes interleukin-11 (IL-11), leukemia inhibitory factor 26 Mar 2021 Gp130 is a transmembrane protein within the IL-6 family of receptor cytokines. Gp130 forms signaling complexes to stimulate the production of 7 Oct 2013 Introduction: Ubiquitously expressed in the human body, glycoprotein 130 ( gp130) is a shared subunit of receptor complexes for at least nine gp130 belongs to the class 1 cytokine receptors. Its extracellular part has been predicted to consist of an N-terminal Ig-like domain. (D1) followed by a CBM (D2.

from my own country, who brings to the table some remarkable genetic models of gastric cancer based on alterations in the gp130/stat3-signaling pathway.

Ord. Cytokinreceptor gp130. Förklaring. 1. Farmakoloisk effekt.

View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003529, Hematopoietin_rcpt_Gp130_CS IPR013783, Ig-like_fold IPR010457, IgC2-like_lig-bd IPR015321, TypeI_recpt_CBD: Pfam i: View protein in Pfam PF00041, fn3, 2 hits PF09240, IL6Ra-bind, 1 hit PF06328, Lep_receptor_Ig, 1 hit: SMART i: View

The Human CD130 (IL-6R-beta, gp130) ELISA is to be used for the in-vitro quantitative determination of soluble CD130 protein (gp130) in human serum, plasma Osteocytic gp130 is required for PTH to increase osteoblast numbers and bone formation in trabecular bone. Male mice were treated with hPTH (1–34) at 30 μg/ kg 18 Jul 2019 Signaling Through gp130 Compromises Suppressive Function in Human FOXP3 + Regulatory T Cells. Khalid Bin Dhuban1,2,3†, Sabrina The gene IL6ST encodes GP130, the common signal transducer of the IL-6 cytokine family consisting of 10 cytokines. Previous studies have identified Absence of GP130 cytokine receptor signaling causes extended Stüve-Wiedemann syndrome. / Chen, Yin Huai; Grigelioniene, Giedre; Newton, Phillip T.; Expansor GP130. 339 kr.

Organism. Homo sapiens (Human) Status. Unreviewed-Annotation score: -Experimental evidence at transcript level i. Names & Taxonomy i. Protein 2017-02-24 · p-CD130/gp130 Antibody (A-12) is a mouse monoclonal IgG 2a κ, cited in 3 publications, provided at 200 µg/ml; specific for an epitope mapping between amino acids Ser 782 Ser 782 of gp130 of human origin Protein Mutation Frequency in Cancer. The 'lollipop plot' above illustrates recurrent (observed in 3 or more out of 4440 TCGA tumor samples from 15 cancer types) and therefore potentially oncogenic missense mutations (click on 'Show Cancer Mutations'). Although gp130 and its dimer partners possess no intrinsic tyrosine kinase domain, the dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors.
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Begär fler bilder. Aktivering av OSMR-gp130-komplexet av OSM utlöser Janus Kinase 1 (JAK1) och Jak2 korsfosforylering av tyrosinrester på det intracellulära receptorområdet. Correlations between unexplained infertility and single nucleotide polymorphism in the genes of leukemia inhibitory factor receptor and gp130. Marwa Malki. Snökedjan SUV RTS 105 från Weissenfels är avsedd för SUV:ar.

Therefore, although LIF binds LIFR and recruits GP130, the definitive role of LIFR and GP130 in implantation remains uncertain.
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Glycoprotein 130 kDa (gp130) is a trans-membrane protein, which is ubiquitously expressed. It serves as the signal transduction unit of a family of cytokines: the IL-6 family.

Klonalitet, Polyclonal. Konjugation, Unconjugated. Reaktivitet, Human,Rat,Mouse. Värd, Rabbit. Original Derbi Kühlerschlauch MULHACEN GP130 (00N03800021) Kühlerschlauch MULHACEN GP130. 16,05 EUR. inkl.